In an interview with the Los Angeles Times, Tobey Maguire revealed a bit more about Spider-Man 3:
"Basically, there's the goo, right? The symbiote which has, like, a dark energy, like the goo from the thing that creates venom." To someone not totally versant in the Spider-Man mythology, Maguire sounds vaguely demented. He realizes it, laughs and backs up. He's not referring to venom, but Venom, "a very, very popular character from the later Spider-Man comics. He has the same kind of attributes that Spider-Man has, but he's just stronger, faster and more vicious than Spider-Man. And it comes from this goo that comes from outer space, so first the goo comes and gets hold of me."
How exactly does it come from outer space? We'll soon know. Hit the link above for the full interview.
Source: Los Angeles Times
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