MTV has posted a quote from James Cromwell talking about Spider-Man 4:
But never fear comic fans, the Stacy family will have a much bigger role to play in future installments, veteran actor James Cromwell told MTV News. Asked if his character, Captain George Stacy, meets the same grisly end in “Spider-Man 3” that he does in the comics, Cromwell playfully replied, “They haven’t shot that [scene] yet. That’s the next one.”
Not much has been confirmed for the fourth Spidey yet, other than that David Koepp is writing the screenplay.