The 18-volume series has previously been adapted in anime form. Published domestically by VIZ Media, the first volume is officially described as follows:
An ice-cold killer is on the loose, and brilliant Dr. Kenzo Tenma is the only one who can stop him! Conspiracies, serial murders, and a scathing indictment of hospital politics are all masterfully woven together in this compelling manga thriller. Tenma risks his promising medical career to save the life of a critically wounded young boy. Unbeknownst to him, the child is destined for a terrible fate. Who could have known that Tenma would create a monster!
Del Toro and Thompson will also executive produce alongside Susan Montford and Gary Ungar. The Japanese publishing company, Shogakukan Inc. will serve as consulting producer.