The Los Angeles Times has posted an interesting interview which includes The Amazing Spider-Man star Andrew Garfield talking about how spider DNA will affect the character. Here's an excerpt from the interview:
What would having spider DNA constituting a percentage of your blood — what would that do? So I studied spiders, I studied their movements and how they operate in the world and I tried to incorporate as much of that as I could. He’s a boy/spider in terms of how he moves, and not just in the suit. It also shapes the way he interacts with people. A spider is so sensitive; their skin is sensitive to everything. That’s the thing with the spider sense and the way he takes in everything. Imagine all of your skin was as sensitive as a spider, the slightest gust of wind would feel like a tornado going by. You’d always be rushing, that rush. What does that do to you? The idea of how he adjusts to that. And I looked at the idea of having more legs, more arms, and the spacial awareness. A spider moves up, down, side-to-side, all around. He’s not linear and with the knowledge of that spatial awareness and the fact that he can be here and then over there incredibly fast. The stillness of a spider and the lightness I found all of that very interesting to explore as well.
You can check out the full interview here!